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Table 1 Percentage of mitochondria exhibiting different types of structural abnormalities in WT and CASQ1-null animals

From: Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice

EDL (4 to 6 months)

Mitochondrial alterations (%)

Total % of altered mitochondria

 

Swollen mitochondria

Containing vacuole

Disruption of ext. membr./int. cristae

Containing myelin figures

WT

1.45

0.80

0.24

0.16

2.65 ± 0.5

CASQ1-null

6.22**

5.66**

1.96**

1.23**

15.08 ± 0.9**

  1. In EDL muscles from 4- to 6-month-old mice, the percentage of mitochondria exhibiting one or more types of structural abnormality (swollen, disrupted internal cristae, vacuoles, or myelin figures) is significantly increased in CASQ1-null mice. Data are means ± SEM (**P < 0.01). CASQ1, skeletal isoform of calsequestrin; WT, wild type.