Donor cells | Donor contribution | Injury model | P value (one-way ANOVA) | ||
---|---|---|---|---|---|
Host mouse | Number of donor nuclei or fibres (mean ± SEM ( n )) | ||||
Irradiation | Cryodamage | Irra+Cryo | |||
Pericytes mdx nude | Human lamin A/C+ nuclei | 51.83 ± 20.01 (6) | 84.17 ± 13.97 (6) | 110.4 ± 56.64 (5) | 0.465 |
S+L fibres | 3.000 ± 1.506 (6) | 27.83 ± 6.421 (6) | 18.20 ± 7.933 (5) | 0.0214* | |
CD133+ mdx nude | Human lamin A/C+ nuclei | 32.50 ± 16.66 (6) | 248.0 ± 35.39 (6) | 195.2 ± 48.64(5) | 0.0012** |
S+L fibres | 14.50 ± 6.980 (6) | 107.0 ± 14.14 (6) | 113.8 ± 25.39 (5) | 0.0008*** | |
Pericytes Rag2-/γ chain-/C5- | Human lamin A/C+ nuclei | 79.55 ± 31.13(11) | 270.9 ± 76.12 (8) | 270.1 ± 69.51 (11) | 0.0424* |
S+L fibres | 15.64 ± 6.33 (11) | 132.6 ± 35.37 (8) | 69.82 ± 21.01 (11) | 0.0036** | |
CD133+ Rag2-/γ chain-/C5- | Human lamin A/C+ nuclei | 98.83 ± 44.22 (6) | 623.2 ± 117.3 (6) | 569.3 ± 104.8 (6) | 0.0023** |
S+L fibres | 18.00 ± 6.583 (6) | 191.3 ± 37.04 (6) | 146.7 ± 18.38 (6) | 0.0004*** |