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Table 3 Metabolic genes downregulated in iMS- Bmal1 −/−

From: The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle

Gene symbol

Gene function

ΔExpression (Tam/Veh)

Student’s t test

Agl

Glycogenolysis

0.83

***

Akt1

Glucose uptake

0.84

**

Il15

Glucose uptake

0.86

*

Pak1

Glucose uptake

0.79

*

Pfkm

Glycolysis

0.81

***

Pgm2

Glycogenolysis

0.87

***

Phka1

Glycogenolysis

0.81

**

Prkab2

Glucose uptake

0.85

*

Prkag2

Glucose uptake

0.83

***

Prkag3

Glucose uptake

0.71

**

Rab10

Glucose uptake

0.86

**

Slc2a3

Glucose uptake

0.35

***

  1. Average gene expression changes of metabolic genes that are significantly downregulated in iMS-Bmal1 −/− skeletal muscle. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.