Figure 1
From: In vitro stability of therapeutically relevant, internally truncated dystrophins
Dystrophin and utrophin constructs analyzed. (A) Diagram of full-length human dystrophin (hDys); NT - N-terminus, CR - cysteine-rich domain, CT - C-terminus, circles - spectrin-like repeats, diamonds - unstructured ‘hinge’ regions, ABD1/2 - actin binding domains, nNOS BD - neuronal nitric oxide synthase binding domain, MTBD - microtubule binding domain, DgBD - dystroglycan binding domain, Syn BD - syntrophin binding domain, DB BD - dystrobrevin binding domain. (B) Diagrams of exon-skipped human dystrophin constructs analyzed. (C) Diagrams of gene therapy human dystrophins analyzed. (D) Diagrams of full-length human utrophin (hUtr) and a micro-utrophin (μH2 hUtr) analyzed.