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Table 4 Age-adjusted Spearman correlations between circulating myostatin levels and body composition, muscle strength, physical activity and biochemical parameters in women and men

From: Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay

Variable

Women (n = 120)

Men (n = 120)

 

r

p value

r

p value

Body composition

 BMI (kg/m2)

0.08

0.414

−0.11

0.250

 Relative ASM (kg/m2)

0.24

0.010

0.24

0.008

 TBLM (kg)

0.21

0.024

0.09

0.339

 TBLM/weight

−0.03

0.772

0.26

0.005

 TBFM (kg)

0.05

0.585

−0.20

0.026

 TBFM/weight

0.05

0.642

−0.27

0.003

Muscle strength

 Grip strength (kg)

0.11

0.239

0.20

0.026

 Knee extensor strength (kg)

0.12

0.211

0.17

0.073

Physical activity

 Energy expenditure (kcal/d)

−0.01

0.928

−0.08

0.376

Biochemical parameters

 FLRG (ng/mL)

0.28

0.002

0.26

0.004

 GASP1 (ng/mL)

0.53

<0.001

0.57

<0.001

 Total 25-(OH)D (ng/mL)

−0.04

0.701

−0.05

0.575

 IGF-1 (ng/mL)

−0.02

0.871

−0.06

0.515

 IGF-2 (ng/mL)

−0.17

0.072

−0.09

0.315

 IGFBP-2 (ng/mL)

−0.14

0.132

−0.07

0.439

 IGFBP-3 (ng/mL)

−0.15

0.115

−0.07

0.464

 Total E1 (pg/mL)

0.03

0.777

0.09

0.309

 Total E2 (pg/mL)

0.02

0.843

0.03

0.778

 Total T (ng/dL)

−0.20

0.027

0.18

0.056

 Bioavailable E2 (pg/mL)

0.11

0.272

0.13

0.158

 Bioavailable T (ng/dL)

0.12

0.188

0.32

<0.001

 SHBG (nmol/L)

−0.29

0.001

−0.13

0.170

  1. Values are presented as Spearman correlation coefficients (r) and p values
  2. BMI body mass index, ASM appendicular skeletal muscle mass, TBLM total body lean mass, TBFM total body fat mass, FLRG follistatin-related gene protein, GASP-1 growth and serum protein-1, 25(OH)D 25-hydroxyvitamin D, IGF insulin-like growth factor, IGFBP insulin-like growth factor binding protein, E 1 estrone, E 2 estradiol, T testosterone, SHBG sex hormone-binding globulin
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Skeletal Muscle

ISSN: 2044-5040

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