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Table 4 Age-adjusted Spearman correlations between circulating myostatin levels and body composition, muscle strength, physical activity and biochemical parameters in women and men

From: Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay

Variable Women (n = 120) Men (n = 120)
  r p value r p value
Body composition
 BMI (kg/m2) 0.08 0.414 −0.11 0.250
 Relative ASM (kg/m2) 0.24 0.010 0.24 0.008
 TBLM (kg) 0.21 0.024 0.09 0.339
 TBLM/weight −0.03 0.772 0.26 0.005
 TBFM (kg) 0.05 0.585 −0.20 0.026
 TBFM/weight 0.05 0.642 −0.27 0.003
Muscle strength
 Grip strength (kg) 0.11 0.239 0.20 0.026
 Knee extensor strength (kg) 0.12 0.211 0.17 0.073
Physical activity
 Energy expenditure (kcal/d) −0.01 0.928 −0.08 0.376
Biochemical parameters
 FLRG (ng/mL) 0.28 0.002 0.26 0.004
 GASP1 (ng/mL) 0.53 <0.001 0.57 <0.001
 Total 25-(OH)D (ng/mL) −0.04 0.701 −0.05 0.575
 IGF-1 (ng/mL) −0.02 0.871 −0.06 0.515
 IGF-2 (ng/mL) −0.17 0.072 −0.09 0.315
 IGFBP-2 (ng/mL) −0.14 0.132 −0.07 0.439
 IGFBP-3 (ng/mL) −0.15 0.115 −0.07 0.464
 Total E1 (pg/mL) 0.03 0.777 0.09 0.309
 Total E2 (pg/mL) 0.02 0.843 0.03 0.778
 Total T (ng/dL) −0.20 0.027 0.18 0.056
 Bioavailable E2 (pg/mL) 0.11 0.272 0.13 0.158
 Bioavailable T (ng/dL) 0.12 0.188 0.32 <0.001
 SHBG (nmol/L) −0.29 0.001 −0.13 0.170
  1. Values are presented as Spearman correlation coefficients (r) and p values
  2. BMI body mass index, ASM appendicular skeletal muscle mass, TBLM total body lean mass, TBFM total body fat mass, FLRG follistatin-related gene protein, GASP-1 growth and serum protein-1, 25(OH)D 25-hydroxyvitamin D, IGF insulin-like growth factor, IGFBP insulin-like growth factor binding protein, E 1 estrone, E 2 estradiol, T testosterone, SHBG sex hormone-binding globulin