Fig. 1
From: Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit
β1a subunit increases RyR1 and RyR2 channel activity in lipid bilayers. a and b Three second (3 s) traces of representative activity from native (a) RyR1 or (b) RyR2 channels recorded at a test potential of +40 mV. Openings are shown as upward inflections from the closed (c) state to the maximum open (o) level. Results are shown before (top panel; control, cis 10 μM [Ca2+] and 2 mM ATP) and after addition of 10 nM β1a subunit (middle panel) and then 100 nM β1a subunit (bottom panel) to the cis chamber. Open probability (P o ) is shown at the right hand corner of each trace