Fig. 2
From: Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit
β1a subunit increases RyR1 and RyR2 channel activity in lipid bilayers. Single-channel gating parameters of RyR1 and RyR2 in response to 10 or 100 nM β1a subunit. a (left) Average relative P o (log10 rel P o ) is the average of the differences between the logarithm of P o following addition of β1a subunit (log10 P oB ) and the logarithm of the control P o (log10 P oC ), where P oC was measured before β1a subunit addition. b (left) Average relative mean open time (log10 rel T c ). c (left) Average relative mean closed time (log10 rel T o ) were calculated in the same way as the average log10 rel P o (above). a–c (right) The average single-channel parameter values are shown right of the corresponding relative values. a–c Single-channel parameters were calculated from ~180 s of channel activity (at +40 and −40 mV). Data are shown for 0 nM β1a (black bar), 10 nM β1a subunit (dark shade bar), and 100 nM β1a subunit (light shade bar), when examined. Error bars indicate ± SEM., n = 7−15 experiments/bar. *p < 0.05 vs control determined using paired (left) or un-paired (right) Student’s t-test, # p < 0.05 vs 10 nM β1a subunit with RyR2 determined by ANOVA