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Fig. 3 | Skeletal Muscle

Fig. 3

From: Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit

Fig. 3

Effects of β1a subunit on the distribution of representative RyR channel open and closed dwell times. Exponential open and closed time constants determined for RyR1 (ac) and RyR2 (df). Open and closed times were collected into logged bins and the square root of the relative frequency of events (probability1/2) was plotted against the logarithm of open (open circles) or closed times (filled circles) in milliseconds. Examples are shown for the data from representative individual channels under control (a, d) and after exposure to 10 nM β1a subunit (b, e) and then 100 nM β1a subunit (c, f). The solid lines represent the fit of multiple exponentials to the data. The individual open time constants (τ o1, τ o2, and τ o3) and individual closed time constants (τ c1, τ c2, and τ c3) are indicated by arrows

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