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Fig. 4 | Skeletal Muscle

Fig. 4

From: Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit

Fig. 4

Effects of β1a subunit on the distribution of RyR channel open and closed dwell times. The probability of open and closed events falling into each time constant is plotted against the respective time constant. The open (τ o , top graphs) and closed (τ c , bottom graphs) time constants and the probability of events in each time constant component were calculated from ~180 s of single channel activity (at +40 and −40 mV). Data is shown for a RyR1 and b RyR2 before (open circle) and after addition of 10 nM β1a subunit (open triangle) or 100 nM β1a subunit (open square), n = 6–12 channel traces. Error bars indicate ± SEM. The individual open time constants (τ o1, τ o2, and τ o3) and individual closed time constants (τ c1, τ c2, and τ c3) are indicated on the top and bottom graphs, respectively. *p < 0.05 vs the probability of events in each time constant in control with 10 nM β1a subunit, determined by ANOVA. # p < 0.05 vs the probability of events in each time constant in control with 100 nM β1a subunit, determined by ANOVA

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