Fig. 7
From: Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit
The K-Q mutation abolishes β1a activation of RyR1 activity. a, b Three second (3 s) traces of WT RyR1 (a) or RyR K-Q mutant (b) activity at +40 mV, opening upward from the closed (c) state to the maximum open (o) level, before (top panel; control, cis 10 μM [Ca2+] and 2 mM ATP) and after addition of 100 nM β1a subunit (bottom panel) to the cis chamber. Open probability (P o ) is shown at the right hand corner of each trace