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Fig. 6 | Skeletal Muscle

Fig. 6

From: Intracellular Ca2+-handling differs markedly between intact human muscle fibers and myotubes

Fig. 6

Human myoblast differentiation into myotubes is paralleled by functional changes in intracellular Ca2+-handling. a Typical example of human myotube and myoblast response to the selective RyR activator 4-CmC and b to the purinergic receptor agonist ATP. Calibration bars indicate scale of fluorescent intensities. c Maximal change in fluorescence expressed as ∆F/F0 following exposure of human myotubes and myoblasts to 4-CmC and ATP, respectively. Data are presented as the mean ± SEM. Asterisk denotes P < 0.05 compared with normal Tyrode throughout, and number sign denotes P < 0.05 relative to myoblasts or myotubes, respectively. d Maximal changes in fluorescent signal expressed as ΔF/F0 in response to 4-CmC vs. ATP in myotubes (closed circles) and myoblasts (open circles)

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