Fig. 1

Effects of adiponectin on different markers of oxidative stress and inflammation in muscles of mdx mice. Tibialis anterior muscles were sampled from 8-week-old WT mice, mdx mice, or mdx mice overexpressing adiponectin (mdx-ApN). Immunodetection was performed with specific antibodies directed against three oxidative stress markers (PRDX3/5, HNE), two pro-inflammatory cytokines (TNFα, IL-1β), one marker of T lymphocytes (CD3), and one macrophage marker (CD68). Representative sections for six mice per group are shown. Scale bar = 25 μm (for PRDX3/5, HNE, TNFα, and IL-1β) and 100 μm (for CD3 and CD68)