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Fig. 1 | Skeletal Muscle

Fig. 1

From: Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

Fig. 1

Effects of myostatin, GDF11, and activin A on Smad2/3 activity. a Smad2/3 activity was recorded as relative luminescence units (RLU) from A204/Smad2/3/Luc reporter cells in the presence of increasing concentrations of myostatin, GDF11, or activin A. Smad2/3 activity in the presence of constant myostatin (b), GDF11 (c), or activin A (d) concentrations and increasing concentrations of control antibody (circles), REGN1033 (squares), and ActR2B-hFc (triangles). e Phospho-Smad2 (p-Smad2) and total Smad2/3 western blot from human skeletal myoblasts in the absence and presence of myostatin, GDF11, or activin A and either control antibody (Control mAb), ActRIIB-hFc, or REGN1033

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Skeletal Muscle

ISSN: 2044-5040

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