Myostatin inhibitors | Ligand | Kinetic binding parameters | |||
---|---|---|---|---|---|
k a (M−1s−1) | k d (s−1) | K D (pM) | T1/2 (min) | ||
REGN1033 | GDF8 | 1.23 × 106 | 2.93 × 10−5 | 23.9 | 394 |
GDF11 | NB | NB | NB | NB | |
Activin A | NB | NB | NB | NB | |
ActRIIB-hFc | GDF8 | 5.98 × 106 | 1.00 × 10−4 | 16.8 | 115 |
GDF11 | 7.38 × 106 | 1.03 × 10−4 | 14.0 | 112 | |
Activin A | 9.17 × 105 | 7.94 × 10−5 | 86.6 | 146 |