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Table 1 Kinetic binding parameters for REGN1033 and ActRIIB-hFc binding to human myostatin, GDF11 and activin A determined by SPR-Biacore

From: Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

Myostatin inhibitors

Ligand

Kinetic binding parameters

k a (M−1s−1)

k d (s−1)

K D (pM)

T1/2 (min)

REGN1033

GDF8

1.23 × 106

2.93 × 10−5

23.9

394

GDF11

NB

NB

NB

NB

Activin A

NB

NB

NB

NB

ActRIIB-hFc

GDF8

5.98 × 106

1.00 × 10−4

16.8

115

GDF11

7.38 × 106

1.03 × 10−4

14.0

112

Activin A

9.17 × 105

7.94 × 10−5

86.6

146

  1. NB no detectable binding