Fig. 2

Regenerative potential of Pax3-induced satellite cells following their transplantation into NSG-mdx ^4Cv mice. Engraftment analysis of control empty vector (a, b) and Pax3-induced cells (iPax3) (c, d). Cross sections of TA muscles harvested from NSG-mdx ^4Cv mice that had been injected with PBS (a, c) or satellite cells (b, d) were stained with antibody to dystrophin (red). Engrafted tissues from control and Pax3-induced cells are represented by mice #03 and #05 and #07 and #09, respectively. DAPI is shown in blue. Scale bar, 50 μm. e Quantification of DYS⁺ myofibers in treated muscles. Error bars represent s.e.m. (n = 6). *P < 0.03