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Fig. 1 | Skeletal Muscle

Fig. 1

From: Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse

Fig. 1

Effect of high fat on embryonic muscle development. EDL muscle morphology at developmental stage E18.5 from wild type (WT) and myostatin null (Mstn−/−) embryos from mice subjected to maternal normal (ND) or a high-fat (HF) diet. a Representative immunofluorescence images depicting primary (slow; red) and secondary (fast; green outline) myotubes from EDL. Scale 100 μm. b Total myotube number in EDL muscle at E18.5. c Myotube cross-sectional area and d myotubes with central nuclei per unit area. e, f Total myotube number of the TA and soleus muscles at E18.5 from WT and Mstn−/− embryos from mothers under a ND or HF diet. ANOVA; (*) P < 0.05 vs. WT ND; (#) P < 0.05 vs. Mstn−/− ND. Data are from N = 6–8 embryos per group

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