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Fig. 10 | Skeletal Muscle

Fig. 10

From: Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse

Fig. 10

Metabonomic analysis of skeletal muscle. Pair-wise comparisons of the metabolic profiles obtained from gastrocnemius muscle from wild type (WT) and myostatin null (Mstn−/−) mice under normal and high-fat diet (ND and HF, respectively). Principal components analysis (PCA) scores plots comparing a WT ND vs. WT HF (PC1 vs. PC2); b WT HF vs. Mstn−/− HF (PC1 vs. PC3); c Mstn−/− ND vs. Mstn−/− HF (PC1 vs. PC3); (% variance explained in the parenthesis). Colour loadings plots shown for d PC2 of the model comparing WT ND vs. WT HF and e PC3 of the model comparing WT HF vs. Mstn−/− HF. Product of PC loadings with standard deviation of the entire data set coloured by the square of the PC loading. f Triglyceride levels in cellular extracts of the gastrocnemius muscle given as fractions. ANOVA; (*) P < 0.05 vs. WT ND; (#) P < 0.05 vs. WT HF; (**) P < 0.05 vs. Mstn−/− ND. N = 4 male mice per group

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