Skip to main content
Fig. 3 | Skeletal Muscle

Fig. 3

From: Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse

Fig. 3

Effect of high-fat diet on body mass, skeletal muscle masses, animal survival curve and cardiac muscle. a Percent changes of body mass in wild type (WT) and myostatin null (Mstn−/−) mice subjected to either a normal (ND) or a high-fat (HF) diet for 10 weeks. ANOVA; (*) P < 0.05 vs. WT ND; (#) P < 0.05 vs. WT HF; (**) P < 0.005 vs. Mstn−/− ND. b Effect of high-fat (HF) diet on EDL, soleus, plantaris, tibialis anterior (TA), gastrocnemius, rectus femoris and vastus lateralis muscle masses. c Animal survival curve in wild type (WT) and myostatin null (Mstn−/−) mice subjected to either a normal (ND) or a high-fat (HF) diet. ANOVA; (*) P < 0.05 vs. WT normal diet (ND); (#) P < 0.05 vs. Mstn−/− ND. A 33 and 45 % reduction of animal survival in Mstn−/− HF diet cohort was observed at the 8-week and 10-week time point, respectively. d Trichrome staining on the heart muscle. Scale 100 μm. e mRNA levels of key markers involved in cardiac hypertrophy and fibrosis. ANOVA; (*) P < 0.05 vs. WT ND, (#) P < 0.05 vs. WT HF; (**) P < 0.005 vs. Mstn−/− ND ; N = 5 male mice per group

Back to article page