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Fig. 5 | Skeletal Muscle

Fig. 5

From: Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse

Fig. 5

Effect of high-fat diet on EDL muscle mitochondrial activity, fibre type and contractile properties. a EDL succinate dehydrogenase (SDH) activity in wild type (WT) and myostatin null (Mstn−/−) mice subjected to a normal (ND) or high-fat (HF) diet for 4 and 10 weeks. Representative histochemical staining for SDH. Scale 100 μm. N = 6 mice per group. b Quantification of SDH-positive (SDH+) fibres among groups. ANOVA; (*) P < 0.05 vs. WT ND; (#) P < 0.05 vs. WT HF. c Fibre type changes on EDL from wild type (WT) and myostatin null (Mstn−/−) mice subjected to a normal (ND) or high-fat (HF) diet for 4 and 10 weeks. ANOVA; (*) P < 0.05 vs. WT ND; (#) P < 0.05 vs. WT HF. N = 6 mice per group. d EDL muscle contractile properties in wild type (WT) and myostatin null (Mstn−/−) mice subjected to a normal (ND) or high-fat (HF) diet. ANOVA; (*) P < 0.05 vs. WT ND; (#) P < 0.05 vs. WT HF. N = 6 mice per group. Exercise fatigue test of from wild type (WT) and myostatin null (Mstn−/−) mice subjected to a normal (ND) or high-fat (HF) diet for 6 weeks. ANOVA; (*) P < 0.05 vs. WT ND; (#) P < 0.05 vs. Mstn−/− ND; (**) P < 0.05 vs. WT HF. N = 5 male mice per group

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Skeletal Muscle

ISSN: 2044-5040

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