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Fig. 8 | Skeletal Muscle

Fig. 8

From: Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse

Fig. 8

Effect of high-fat diet on body fat contents and on white adipose tissue gene expression. a Visceral fat deposition in WT and Mstn−/− mice subjected to either a ND or a HF diet. Note the excessive fat contents in the Mstn−/− HF cohort. White adipose tissue (WAT) gene expression levels of b key factors regulating fatty acid uptake (i.e. Cd36, Cpt1b, Slc25a20, Cpt2, Fatp1 and Fabp3), c fatty acid oxidation (i.e. Acadl and Acadm) and Ucp1. d Fatty acid transcriptional regulator Ppara and regulator of Upc1-Fndc5/irisin. ANOVA; (*) P < 0.05 vs. WT ND; (#) P < 0.05 vs. WT HF; (**) P < 0.05 vs. Mstn−/− ND. N = 6 mice per group. e Representative immunoblot for ucp1 protein. N = 3 male mice per group

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Skeletal Muscle

ISSN: 2044-5040

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