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Table 1 MyHC protein expression correlates with AAV9- but not with AAV6-mediated transduction

From: Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9

 

Model 1: Myofiber types

Model 2: Myofiber types and CSA

AAV6 (N = 185)

AAV9 (N = 202)

AAV6 (N = 185)

AAV9 (N = 202)

 

β for GFP (SE)

P value

β for GFP (SE)

P value

β for GFP (SE)

P value

β for GFP (SE)

P value

MyHC-2b

−0.12 (0.07)

0.070

−0.38 (0.06)

<0.001

−0.07 (0.06)

0.23

−0.27 (0.07)

<0.001

MyHC-2a

0.25 (0.09)

0.007

−0.24 (0.07)

<0.001

−0.15 (0.10)

0.12

−0.38 (0.08)

<0.001

MyHC-1

−0.38 (0.28)

0.170

0.80 (0.13)

<0.001

−0.03 (0.25)

0.91

0.84 (0.12)

<0.001

  1. Linear regression analyses were performed including mean fluorescent intensities (MFI) for GFP as a dependent variable. In model 1, MFIs of myofibers expressing MyHC-2b, MyHC-2a, and MyHC-1 isotypes were included as independent variables. In model 2, cross-sectional area (CSA) of the myofibers was additionally included as an independent variable. Models were stratified for AAV6 and AAV9. Beta of the regression analysis and standard errors (SE) are provided
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Skeletal Muscle

ISSN: 2044-5040

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