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Fig. 3 | Skeletal Muscle

Fig. 3

From: Reduced voluntary running performance is associated with impaired coordination as a result of muscle satellite cell depletion in adult mice

Fig. 3

Eight weeks of voluntary wheel running resulted in a shift in myosin heavy chain isoform distribution and an increase in SDH staining in mouse plantaris muscles, independent of satellite cell depletion. a–d Representative images of plantaris muscle cross sections were examined immunohistochemically for myosin heavy chain myosin (MyHC) type IIa (green), MyHC IIb (red), and MyHC IIx (unstained/black). Scale bar = 100 μm. e Quantification of relative frequency of MyHC expression. Data are presented as mean relative frequency ± S.E.M. f–i Representative ×20 images of SDH staining from each experimental group. j Quantification of SDH positive fibers as a percent of total fibers; (−) negative fibers, (+) weakly positive staining fibers, (++) strongly positive staining fibers. Values are mean ± SE. Number sign indicates a significant difference between treatment-matched ambulatory and running animals. Significance was set at p ≤ 0.05

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Skeletal Muscle

ISSN: 2044-5040

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