Fig. 7

Satellite cell depletion resulted in a pronounced reduction in functional outcomes pertaining to strength, coordination, and balance. To assess functional measures beyond running performance, vehicle- and tamoxifen-treated adult female Pax7/DTA mice were subjected to a battery of functional tests. a Grip strength was measured using a specialized force transducer and reported as (N/g of body weight). b Gait analysis was performed as part of a standard observational battery. Vehicle- and tamoxifen-treated animals were separated into two categories those with normal gaits or impaired gaits. The two experimental conditions were evaluated using a chi-squared test. c–d A Rotor-Rod apparatus was used to evaluate motor coordination and balance. The results are reported as latency to fall (s) (c) and distance traveled on the rod (cm) (d). e Balance beams of varying widths were used to specifically assess balance, with total time to traverse each beam (seconds) as an endpoint measurement. Asterisk indicates significant difference between vehicle and tamoxifen. Values are means ± SE. Significance was set at p ≤ 0.05