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Fig. 8 | Skeletal Muscle

Fig. 8

From: Reduced voluntary running performance is associated with impaired coordination as a result of muscle satellite cell depletion in adult mice

Fig. 8

Increased extracellular matrix and decreased intrafusal fiber cross-sectional area in Pax7+ cell depleted mice. Representative images of muscle spindle fibers from plantaris muscles of vehicle (a and c)- and tamoxifen-treated (b and d) mice. Plantaris muscle cross sections were examined immunohistochemically for Pax7 (red), laminin (green), and counterstained with DAPI (blue) (a–b). Representative images of spindle fibers stained with WGA (c and d). Scale bars represent 50 μm. Quantification of area occupied by WGA within spindle capsules and enclosed intrafusal fibers normalized to muscle spindle circumference (e). Values are reported as the extracellular matrix (ECM) index. Mean intrafusal fiber cross-sectional area (μm2) within individual muscle spindles was quantified by tracing WGA-stained intrafusal fibers (f). Asterisk indicates significant difference between vehicle and tamoxifen. Values are means ± SE. Significance was set at p ≤ 0.05

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Skeletal Muscle

ISSN: 2044-5040

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