Fig. 1

Higher relative numbers of CD49d^hi T cells correlate with rapid disease progression. a CD49d membrane expression in CD4⁺ and CD8⁺ T cell subsets. The values correspond to the percentages of the T cell subpopulation with a high CD49d expression (CD49d^hi T). Dashed bars define high versus low CD49d expression, and the red curves represent isotype-matched antibody. b Relative numbers of CD49d^hiCD4⁺ and CD49d^hiCD8⁺ T cells in different groups of DMD patients organized according to their disease progression, as well as healthy controls. c Retrospective study of wheelchair-bound patients organized according to the age when they lost ability to walk. d Prospective study in patients able to walk 1 m/s or less, organized according to the age when they became wheelchair bound. The number of DMD patients analyzed in each group appears in parentheses. b *p < 0.05, **p < 0.01, ***p < 0.001