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Fig. 1 | Skeletal Muscle

Fig. 1

From: Prenatal muscle development in a mouse model for the secondary dystroglycanopathies

Fig. 1

Skeletal development, body weight and skeletal muscle development. A comparison of alizarin blue staining of wild type (a) and FKRPKD (b) pups at P0 indicated no differences with respect to skeletal development. c Body weight was significantly lower in FKRPKD (p = 0.0069) relative to wild type; there was no significant difference in body weight between wild type and heterozygous mice. Tibia/femur length was measured using micro-computed tomography and showed no significant differences between FKRPKD and wild type at P0. Data was analysed by one-way ANOVA. d Transverse sections of the hindlimb muscle at E15.5 and P0 immunolabelled for slow myosin heavy chain. The proportion of myotubes expressing slow myosin heavy chain was similar between FKRPKD and wild type. At P0, fewer myotubes/fibres expressed slow myosin, with those still positive distributed in the superficial area of the TA and EDL. In the soleus which is a slow postural muscle in the adult, slow myosin continued to be expressed in most of myotubes/fibres

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