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Fig. 8 | Skeletal Muscle

Fig. 8

From: Prenatal muscle development in a mouse model for the secondary dystroglycanopathies

Fig. 8

Myoblast fusion at E15.5. Myoblasts were isolated from the limbs at E15.5 for the further evaluation of reduction in cluster size that we observed on transverse sections. The myogenic fusion index calculated by counting the proportion of nuclei contained within myotubes showed a significant reduction in FKRPKD relative to wild type (a). Desmin immunolabelling further showed that the number of myotubes that formed 4–5 days after plating on Matrigel pre-coated coverslips was reduced in the FKRPKD (n = 6 wild type and 6 FKRPKD pups) (b)

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