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Fig. 10 | Skeletal Muscle

Fig. 10

From: Attenuated Ca2+ release in a mouse model of limb girdle muscular dystrophy 2A

Fig. 10

Comparison of Ca2+ transients at the triads and the M and the Z lines of WT and C3KO fibers. a Average Ca2+ transients at the triads (blue trace), the Z line (red trace), and the M line (black trace) calculated from a population of 12 WT fibers. b Equivalent data from a population of C3KO fibers (n = 6). The insets in (a) and (b) show representative single sweep Ca2+ transients recorded at the triad (T), Z line (Z), and M line (M) of a WT and a C3KO fiber, respectively. c Comparison of the average peak value of ΔF/F transients recorded at the triads, Z lines, and M lines. The asterisks indicate statistical significance (p < 0.05). d, e The average Ca2+ fluxes at the T sites (predicted by model simulations) for WT and C3KO fibers, respectively

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