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Table 1 Descriptive characteristics of healthy controls and patients with COPD

From: Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle

Characteristics

Control (n = 19)

COPD (n = 29)

Age, years

68 ± 6

66 ± 5

Smoking, pack-years

3.4 ± 10.4

64.4 ± 37.1*

Weight, kg

80.1 ± 14.2

71.2 ± 17.2

Height, m

171.9 ± 4.4

169.7 ± 7.5

BMI, kg/m2

26.8 ± 3.8

28.8 ± 11.9

FEV1, % pred

107.9 ± 21.9

40.7 ± 13.9*

FEV1/FVC, % pred

78.5 ± 7.3

51.4 ± 13.9*

TLC, % pred

103.1 ± 13.3

122.2 ± 17.2*

RV, % pred

95.8 ± 37.1

172.1 ± 37.4*

DLCO, % pred

105.3 ± 14.3

53.2 ± 16.7*

Peak VO2, % pred

92.2 ± 17.4

38.4 ± 13.3*

Peak work, % pred

112.3 ± 21.6

36.5 ± 19.3*

Fiber CSA (μm2)

5684.6 ± 1328.7

5007.9 ± 1181.4

Fiber type 1, %

48.10 ± 20.3

24.0 ± 9.8*

Type II shiftersa, %

20

73*

  1. Values presented as mean ± SD
  2. Abbreviations: COPD chronic obstructive pulmonary disease, BMI body mass index, FEV 1 forced expiratory volume in one second , FVC forced vital capacity, TLC total lung capacity, RV residual volume, DLCO lung diffusion capacity, CSA cross section area
  3. *p < 0.05
  4. aNumber of patients with <27 % myosin heavy chain type 1 fibers
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Skeletal Muscle

ISSN: 2044-5040

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