Fig. 1
From: Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism
Alterations of mTORC1 signaling in the skeletal muscle affects whole-body metabolism. a Body weight is lower in TSCmKO (n = 10) and RAmKO (n = 17) mice at 10 weeks of age when compared to control (Ctrl) mice (n = 14). b–c Lean mass (b) is lower in TSCmKO (n = 13) and RAmKO (n = 16) mice while fat mass (c) is only decreased in TSCmKO mice (n = 6) when compared to control (Ctrl) mice at 10 weeks of age (n = 21). d–e Plasma insulin levels (d) and glucose levels (e) are decreased in 10-week-old TSCmKO mice (n = 12) while they are unchanged in 10-week-old RAmKO mice (n = 6) when compared to control (Ctrl) mice (n = 10). f Plasma lactate levels are increased in 10-week-old TSCmKO mice (n = 6) while they are unchanged in 10-week-old RAmKO mice (n = 6) when compared to control (Ctrl) mice (n = 12). g–h TSCmKO (n = 6) but not RAmKO mice (n = 6) show glucose intolerance in a GTT (g) while RAmKO (n = 6) but not TSCmKO mice (n = 6) show insulin resistance in an ITT (h) at 10 weeks of age when compared to control (Ctrl) mice (n = 10). Data presented are all from male mice of the indicated genotypes. Data represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001