Fig. 5
From: Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism
Myopathy pre-dominates the metabolic changes at higher age. a Body weight is decreased in both TSCmKO (n = 8) and RAmKO (n = 4) mice at 40 and 20 weeks of age, respectively, when compared to control (Ctrl) littermates (n = 9). b–c Both lean mass (b) and fat mass (c) are decreased in TSCmKO (n = 10) and RAmKO (n = 8) mice at 40 and 20 weeks of age, respectively, when compared to control (Ctrl) littermates (n = 10). d–e Both plasma insulin (d) and glucose (e) levels are decreased in TSCmKO (n = 8) and RAmKO (n = 5) mice at 40 and 20 weeks of age, respectively, when compared to control (Ctrl) littermates (n = 12). f Plasma lactate levels are unchanged in 40-week-old TSCmKO (n = 3) and 20-week-old RAmKO (n = 3) mice compared to control (Ctrl) littermates (n = 6). g–h TSCmKO (n = 5) and RAmKO mice (n = 5) show normal glucose tolerance (h) and develop insulin resistance (i) at 40 and 20 weeks of age, respectively, when compared to control (Ctrl) littermates (n = 10). i Oil Red O staining of the gastrocnemius muscle in 40-week-old TSCmKO and RAmKO mice indicates increased lipid accumulation (n = 3). Scale bar: 100 μm. Data presented are all from male mice of the indicated genotypes. Data represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001