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Table 2 CLAMS analysis of TSCmKO and RAmKO mice on a HFD

From: Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism

 

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TSCmKO

P

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RAmKO

P

Drink (ml/g/day)

0.11 ± 0.04

0.16 ± 0.02

**

0.15 ± 0.03

0.15 ± 0.06

NS

Feed (g/g/day)

0.21 ± 0.06

0.36 ± 0.12

*

0.27 ± 0.02

0.29 ± 0.13

NS

CO2 (l/g/day)

0.24 ± 0.03

0.32 ± 0.02

***

0.29 ± 0.04

0.30 ± 0.04

NS

O2 (l/g/day)

0.31 ± 0.04

0.41 ± 0.02

**

0.36 ± 0.04

0.40 ± 0.06

NS

RER

0.75 ± 0.01

0.77 ± 0.01

**

0.79 ± 0.01

0.75 ± 0.01

**

Heat (kcal/h/g)

0.021 ± 0.00

0.028 ± 0.00

**

0.019 ± 0.00

0.020 ± 0.00

NS

X-amb (counts/h)

557.5 ± 122.4

616.9 ± 80.6

NS

601.2 ± 103.8

294.7 ± 71.1

**

Y-amb (counts/h)

55.5 ± 7.8

79.1 ± 25.1

0.05

49.4 ± 10.5

42.3 ± 15.9

NS

  1. Student’s t test. Values represent mean ± SEM over a period of 4 days. Data presented are of male mice. X-amb and Y-amb refer to ambulatory movement measured by laser counts in X and Y coordinates
  2. NS not significant
  3. *p < 0.05
  4. **p < 0.01
  5. ***p < 0.001 (n = 6)