Skip to main content

Table 3 CLAMS analysis of 40-week-old TSCmKO and 20-week-old RAmKO mice

From: Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism

  Ctrl TSCmKO P Ctrl RAmKO P
Drink (ml/g/day) 0.18 ± 0.05 0.22 ± 0.07 NS 0.23 ± 0.11 0.14 ± 0.03 NS
Feed (g/g/day) 0.31 ± 0.09 0.40 ± 0.12 NS 0.37 ± 0.19 0.44 ± 0.13 NS
CO2 (l/g/day) 0.28 ± 0.03 0.32 ± 0.04 * 0.25 ± 0.05 0.26 ± 0.02 NS
O2 (l/g/day) 0.32 ± 0.03 0.37 ± 0.04 * 0.28 ± 0.05 0.30 ± 0.03 NS
RER 0.85 ± 0.05 0.88 ± 0.05 NS 0.88 ± 0.04 0.87 ± 0.01 NS
Heat (kcal/h/g) 0.022 ± 0.00 0.028 ± 0.00 * 0.026 ± 0.00 0.028 ± 0.00 NS
X-amb (counts/h) 884.1 ± 316.4 578.1 ± 113.1 0.05 820.7 ± 247.7 856.6 ± 434.9 NS
Y-amb (counts/h) 117.1 ± 43.1 75.8 ± 19.5 0.09 100.2 ± 56.4 130.0 ± 48.8 NS
  1. Student’s t test. Values represent mean ± SEM over a period of 3 days. Data presented are of male mice. X-amb and Y-amb refer to ambulatory movement measured by laser counts in X and Y coordinates
  2. NS not significant
  3. *p < 0.05 (n = 6)