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Table 3 CLAMS analysis of 40-week-old TSCmKO and 20-week-old RAmKO mice

From: Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism

 

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TSCmKO

P

Ctrl

RAmKO

P

Drink (ml/g/day)

0.18 ± 0.05

0.22 ± 0.07

NS

0.23 ± 0.11

0.14 ± 0.03

NS

Feed (g/g/day)

0.31 ± 0.09

0.40 ± 0.12

NS

0.37 ± 0.19

0.44 ± 0.13

NS

CO2 (l/g/day)

0.28 ± 0.03

0.32 ± 0.04

*

0.25 ± 0.05

0.26 ± 0.02

NS

O2 (l/g/day)

0.32 ± 0.03

0.37 ± 0.04

*

0.28 ± 0.05

0.30 ± 0.03

NS

RER

0.85 ± 0.05

0.88 ± 0.05

NS

0.88 ± 0.04

0.87 ± 0.01

NS

Heat (kcal/h/g)

0.022 ± 0.00

0.028 ± 0.00

*

0.026 ± 0.00

0.028 ± 0.00

NS

X-amb (counts/h)

884.1 ± 316.4

578.1 ± 113.1

0.05

820.7 ± 247.7

856.6 ± 434.9

NS

Y-amb (counts/h)

117.1 ± 43.1

75.8 ± 19.5

0.09

100.2 ± 56.4

130.0 ± 48.8

NS

  1. Student’s t test. Values represent mean ± SEM over a period of 3 days. Data presented are of male mice. X-amb and Y-amb refer to ambulatory movement measured by laser counts in X and Y coordinates
  2. NS not significant
  3. *p < 0.05 (n = 6)