Skip to main content

Table 2 Differences between GRMD (Mstn +/+) and GRippet (Mstn +/−) dogs (significant (p < 0.05) and trending (p < 0.2))

From: Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures

Test

GRippets (Mstn +/−) (mean ± SD)

GRMD (Mstn +/+) (mean ± SD)

p value

Joint angles

 Maximal hip joint flexion angle (o)

77.5 ± 4.93

63.0 ± 3.61

0.05

 Maximal tarsal joint flexion angle (o)

53.5 ± 7.85

35.0 ± 7.0

0.05

 Maximal stifle joint flexion angle (o)

42.0 ± 5.35

34.0 ± 3.61

0.173

 Tarsal range of motion (o)

104 ± 8.73

123 ± 4.04

0.052

Magnetic resonance imaging

 Rectus femoris percent cross-sectional area

2.70 ± 0.76

4.29 ± 0.30

0.168

 Quadriceps femoris percent cross-sectional area

15.9 ± 0.61

21.6 ± 0.94

0.162

 CS/VL ratio (volume and percent cross-sectional area)

0.86 ± 0.19

0.48 ± 0.04

0.168

Molecular/histopathology

 Lateral head gastrocnemius myostatin mRNA fold change

1.35 ± 0.682

0.565 ± 0.454

0.192

 Overall average degenerating fibers (%)

2.58 ± 0.36

3.97 ± 1.21

0.082

 Cranial sartorius fiber cross-sectional area (mm2)

4,133 ± 233

2,661 ± 316

0.01

 Cranial sartorius centrally nucleated fibers (%)

20.7 ± 3.82

11.4 ± 5.23

0.132