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Table 3 Joint angles in non-dystrophic control, GRMD (Mstn +/+), and GRippet (Mstn +/−) dogs

From: Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures

Genotype Tarsal joint (mean ± SD) Stifle joint (mean ± SD) Hip joint (mean ± SD)
Original Flexion Extension ROM Flexion Extension ROM Flexion Extension ROM
Controls 150 ± 11.1 45.0 ± 8.0 153 ± 6.43 108 ± 11.0 39.3 ± 6.03 146 ± 14.0 107 ± 11.4 58.3 ± 5.51b** 146 ± 10.4 87.7 ± 15.9b*
GRMD (Mstn +/+ ) 153 ± 12.0 35.0 ± 7.0b* 158 ± 11.0 123 ± 4.04 34.0 ± 3.61 138 ± 5.0 104 ± 7.94 63.0 ± 3.61b* 140 ± 10.8 76.7 ± 13.3
GRippet (Mstn +/− ) 147 ± 19.4 53.5 ± 7.85a* 157 ± 12.5 104 ± 8.73 42.0 ± 5.35 140 ± 5.26 97.5 ± 6.56 77.5 ± 4.93a* 134 ± 13.3 56.5 ± 12.5
  1. ROM range of motion
  2. aSignificantly different (*p < 0.05) from GRMD dogs
  3. bSignificantly different (*p < 0.05; **p < 0.01) from GRippets