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Fig. 3 | Skeletal Muscle

Fig. 3

From: Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

Fig. 3

Four-week daily RAPA treatment improves functional outcomes in Myf5/Fktn KO mice. a Force-frequency curves showing in vivo force measurements taken from tibialis anterior muscles of daily RAPA study mice prior to and at completion of RAPA or VEH dosing. Two-way repeated measures ANOVA with Bonferroni’s post-test. *p < 0.05; **p < 0.01; ***p < 0.001. n = 5 mice per group. b Comparison of downhill treadmill distances run by VEH and RAPA KO mice. Data are presented as the proportion of KO distance normalized to respective age- and treatment-matched LC mice from the same treadmill run. Two-tailed Student’s t test. *p < 0.05. n = 7 mice per group. c Serum creatine kinase analysis of tail vein bleeds taken from daily RAPA study mice at the end of dosing (left, pre-tread) or 2 h after a downhill run to exhaustion (right, post-tread). Two-way ANOVA with Bonferroni’s post-test of all pairs. *p < 0.05; **p < 0.01; ***p < 0.001. n = 6, VEH and RAPA LC; n = 7, VEH and RAPA KO

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