Fig. 6

L-type currents and charge movements are reduced in early-symptomatic SOD1^G93A FDB fibers. Representative L-type currents elicited by 500 ms depolarizations from −80 to −20, 0, 20, and 40 mV are shown for a wild-type FDB fiber (a) and an early-symptomatic SOD1^G93A fiber (b). c Peak I-V relationships corresponding to the current families are shown in panels (a) and (b). Representative charge movement recordings elicited by 25 ms depolarizations from −80 to −40, −20, 0, 20 mV are shown for a wild-type (d) and a pre-symptomatic SOD1^G93A fiber (e). f Q-V relationships. The smooth curves in panels (c) and (f) are plotted according to Eq. 2 and Eq. 3, respectively, with fit parameters displayed in Table 2