Skip to main content
Fig. 6 | Skeletal Muscle

Fig. 6

From: Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration

Fig. 6

Syndecan-3 regulates satellite cell-niche interactions and satellite cell homeostasis. In wild type muscle (WT, top drawing) satellite cells (light blue cells) activate in response to myofiber injury and self-renew via asymmetric cell division (1) or proliferate as myoblasts (green cells) either underneath the basal lamina (yellow) or outside their niche, in the endomysium, and eventually differentiate (red mononucleated cells) to fuse to damaged myofibers or to one another. In Sdc3 −/− muscle (S3−/−, bottom drawing), satellite cell self-renewal is decreased (2) leading to increased numbers of activated myoblasts, which proliferate mostly outside the niche, due to reduced adhesiveness to the myofiber. The increased number of proliferating myoblasts provides for increased numbers of differentiated myocytes that fuse to damaged myofibers leading to larger, hyperplastic regenerated myofibers. Since satellite cell self-renewal is decreased, a population of activated and proliferating myoblasts persists. Other myogenic progenitor cells distinct from satellite cells and possibly derived from blood vessel-associated progenitors (gray cells) may participate in muscle regeneration in Sdc3 −/− muscles

Back to article page