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Fig. 2 | Skeletal Muscle

Fig. 2

From: VAChT overexpression increases acetylcholine at the synaptic cleft and accelerates aging of neuromuscular junctions

Fig. 2

The impact of increasing ACh was determined by recording miniature endplate potentials (MEPPs) in the diaphragm of young adult control and VAChTHyp mice. The frequency of MEPPs is unchanged in VAChTHyp mice (a), with error bar representing the standard error. However, the average MEPP amplitude is higher in VAChTHyp (n = 2297 events) compared to that in control mice (n = 2444 events) (bd). The amplitude of MEPPs was on average significantly higher in VAChTHyp mice using a Kolmogorov-Smirnov test (d; P value <0.001). Results are from 50 muscle fibers from five mice per genotype. Error bar = Standard Error. Four-month-old male mice on a C57BL/6 background were used for these experiments

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