Fig. 7
VAChTHyp mice exhibit motor deficits in middle age. At 5 months of age, VAChTHyp mice do not exhibit body weight loss (a) or motor function deficits (b, c). Thirteen-month-old VAChTHyp mice weigh the same (d) and perform equally well on a rotarod (f) as control mice of the same age. However, the hanging test revealed motor deficits in 13-month-old VAChTHyp mice (e). Only female mice maintained on a C57BL/6 background were used for these experiments. Eight control and 12 VAChThyp mice were examined on the hanging and rotarod tests at both ages. Error bar = Standard Error. *P value <0.05, **P value <0.01