From: The functional significance of the skeletal muscle clock: lessons from Bmal1 knockout models
 | Whole body Bmal1 KO | Muscle-specific Bmal1 KO | ||||
---|---|---|---|---|---|---|
Standard | Standard + rescue with mBmal1 a | Inducible | Standard | Inducible | ||
Circadian locomotor rhythm | No | No | No | Yes | Yes | Yes |
Total activity level | ↓ | = | = | ↑ | = | = |
Life span | ↓ | = | = | = | = | ND |
Body weight | ↓ | = | = | = | = | ND |
Muscle weight | ↓ | ND | NDb | ↑ | = | ND |
Muscle fiber CSA | ↓ | ND | ND | ↑ | = | = |
Muscle force (normalized) | ↓ | ND | ND | ↓ | = | ↓ |
Muscle fiber-type profile (fast muscles) | ND | ND | ND | ↓ 2X | = | ↓ 2B |
References | [32] | [30] | [27] | [27] |