Fig. 1
From: Heme oxygenase and carbon monoxide protect from muscle dystrophy
Inhibition of VEGF signaling worsens dystrophy. a Dual transgenic system to express both sFlt1 in the muscle only and only in absence of doxycycline. MCK muscle creatine kinase promoter, tTA tetracycline-suppressed transactivator, TRE tTA-responsive promoter. b Western blotting of sFlt1 demonstrating induction of sFlt1 in the muscle (top) and absence of spilling of sFlt1 into the circulation (bottom). c–e Serum creatine kinase levels (c), % Evans blue dye extravasation (d), and % central nuclei in gastrocnemius muscle (e) from mdx mice bearing the indicated transgenes. Scale bar = 50 μm. n = 8. *P < 0.05, Student’s t test. Error bars indicate ±SEM