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Fig. 8 | Skeletal Muscle

Fig. 8

From: Laminin 521 maintains differentiation potential of mouse and human satellite cell-derived myoblasts during long-term culture expansion

Fig. 8

Laminin 521 supports improved human myogenic cell differentiation. a Cells expanded on laminin 521 and MG show significant differentiation after five passages in vitro, MHC (green), Hoechst (blue). b MHC area quantification shows increased differentiation in laminin 521 cultures and better stability compared to MG. c MHC/nuclear ratios show laminin 521 and MG differentiated cells display hypertrophy. Error bars represent ±S.D. Scale bar represents 200 μm. N = 10 technical replicates from one biological source. Significance was determined by one-way ANOVA with Bonferroni correction. Significance is annotated as less than .05 (*), less than .01 (**), and less than .0001 (****). All comparisons were conducted using laminin 521 as control

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Skeletal Muscle

ISSN: 2044-5040

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