Fig. 3From: Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weaknessSLK knockout muscles develop central nuclei and decreased force generation. Hematoxylin and eosin staining on 12-week (a, b) and 24-week (c, d) animals from each genotype. A high proportion of central nuclei (arrow) appeared in numerous sections from SLK-null mice (8% of total nuclei). e, f Electron photomicrographs from 24-week-old skeletal muscles showing enlarged and degenerating mitochondria (asterisk). g Western blot analysis of 24-week-old skeletal muscles reveals increased levels of active p38. The Soleus (h) and EDL (i) muscle fibers were subjected to force measurement assays (7 wild types, 10 knockouts). Maximal specific force was significantly decreased in knockout musclesBack to article page