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Fig. 4 | Skeletal Muscle

Fig. 4

From: Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

Fig. 4

Repetitiveness of the mitoflash signal is reduced by field stimulation and CsA treatment. The temporal profile of an individual mitoflash patch at a local fiber region is illustrated for the conditions of denervation (Den) (a), denervation after 120 s of field stimulation (Den + Stim) (b), denervation plus CsA treatment (Den + CsA) (c), and the sham muscle fiber (d). Three representative 3D surface plots of the mitoflash patch for each condition are presented in the lower panels. e The summary bar graph for quantification of the re-occurrence numbers during the 100 sequential images (n = 10 for each group, *p < 0.01). Note that both field stimulation and CsA treatment reduced the repetitiveness of the mitoflash signal induced by the denervation

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