Fig. 4From: Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervationRepetitiveness of the mitoflash signal is reduced by field stimulation and CsA treatment. The temporal profile of an individual mitoflash patch at a local fiber region is illustrated for the conditions of denervation (Den) (a), denervation after 120 s of field stimulation (Den + Stim) (b), denervation plus CsA treatment (Den + CsA) (c), and the sham muscle fiber (d). Three representative 3D surface plots of the mitoflash patch for each condition are presented in the lower panels. e The summary bar graph for quantification of the re-occurrence numbers during the 100 sequential images (n = 10 for each group, *p < 0.01). Note that both field stimulation and CsA treatment reduced the repetitiveness of the mitoflash signal induced by the denervationBack to article page