Skip to main content
Fig. 5 | Skeletal Muscle

Fig. 5

From: The golden retriever model of Duchenne muscular dystrophy

Fig. 5

Canine dystrophin protein (Ensembl protein ID ENSCAFP00000031637), with mutation information for 10 dog breeds with dystrophinopathies. The breeds are Pembroke Welsh Corgi [98], Labrador retriever [97], Tibetan terrier [97], Cocker spaniel [97], golden retriever [96], Japanese Spitz [99], Norfolk terrier [100], German shorthaired pointer [101, 102], two distinct mutations in the Cavalier King Charles spaniel [103, 104], and Rottweiler [105]. CH indicates actin-binding calponin homology domains. The “WWP” domain binds proline-rich polypeptides and is the primary interaction site for dystrophin and dystroglycan. EF indicates members of the EF-hand family domain that stabilizes the dystrophin-dystroglycan complex. ZNF represents a putative zinc-binding domain, ZnF_ZZ is present in dystrophin-like proteins and may bind to calmodulin. All 79 exons are represented. Exons and protein domains are approximately shown to scale. Insertion and deletion mutations are shown above the exons. At the bottom of the figure, the German shorthaired pointer (GSHP) DMD gene deletion and point mutations are identified with a hatched line and arrows, respectively. Modified from reference [70]

Back to article page