Fig. 7

Averaged MRI segmentation of dogs with variable GRMD and myostatin (Mstn) genotypes. T2-FS MRI images of pelvic limb muscles in the transverse plane at the level of the midthigh are shown in non-dystrophic control (a), dystrophic GRMD, wild-type Mstn ^+/+ (b) and GRMD, heterozygous null Mstn ^+/− (GRippet) (c) dogs. Note the proportional enlargement of the sartorius and hamstring muscles and the associated atrophy/hypoplasia of the quadriceps femoris of the GRMD, wild-type Mstn ^+/+ dogs, relative to the non-dystrophic control dogs, and the even more dramatic differential size of these muscles in the GRippet Mstn ^+/− dogs. From reference [158]