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Fig. 1 | Skeletal Muscle

Fig. 1

From: Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice

Fig. 1

Conditional depletion of satellite cells (Pax7+) in young and mature mice before synergist ablation surgery to overload the plantaris muscle for 10 days (OV). a Study design schematic demonstrating the duration of vehicle (satellite cell-replete, SC+) and tamoxifen (satellite cell-depleted, SC-) treatment, washout, and sham or OV surgery in young and mature mice. be Immunohistochemistry (IHC) representative images visualizing b laminin (green), c myonuclei (blue), d Pax7 (red), and e merged fields, where satellite cells are identified as Pax7+/DAPI+. White arrows denote the same satellite cell in each image; scale bar=20 μm. f Satellite cell density in young sham (n = 7 SC+, n = 6 SC-) and OV (n = 8 SC+, n = 6 SC-) mice. g Satellite cell density in mature sham (n = 9 SC+, n = 7 SC-) and OV (n = 6 SC+, n = 7 SC-) mice. *p < 0.05 compared to analogous SC+ group

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