Fig. 4
Average muscle fiber cross-sectional area (CSA) increases in young and mature satellite cell-replete (SC+) and mature satellite cell-depleted mice (SC-), but not young SC- mice after synergist ablation overload of the plantaris for 10 days (OV). IHC representative images visualizing muscle fiber borders (pink) in a young sham (SC+, SC-) and OV (SC+, SC-) mice, and b mature sham (SC+, SC-) and OV (SC+, SC-) mice; scale bar=20 μm. c Average muscle fiber CSA in young sham (n = 7 SC+, n = 6 SC-) and OV (n = 8 SC+, n = 6 SC-) mice, excluding fibers <300 μm2. d Average muscle fiber CSA in mature sham (n = 9 SC+, n = 7 SC-) and OV (n = 6 SC+, n = 7 SC-) mice, excluding fibers <300 μm2, but including eMyHC+ fibers. e Average muscle fiber CSA in mature mice, excluding fibers <300 μm2, as well as eMyHC+ fibers. *p < 0.05 compared to respective sham