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Table 2 Insulin signaling intermediates

From: Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass

 

Gastrocnemius

Soleus

WT mice (n = 9)

bGH mice (n = 9)

WT mice (n = 9)

bGH mice (n = 9)

Insulin receptor β (AU)

1.50 ± 0.01

0.80 ± 0.05 ***

2.08 ± 0.24

1.23 ± 0.18 *

p-IRS-1Ser307 (AU)

0.76 ± 0.07

1.09 ± 0.14 *

0.84 ± 0.23

1.46 ± 0.25

IRS1 total (AU)

1.59 ± 0.21

2.57 ± 0.44

1.57 ± 0.33

1.10 ± 0.31

p-AS160Ser588 (AU)

0.40 ± 0.03

0.49 ± 0.05

1.67 ± 0.40

1.85 ± 0.29

p-AS160Ser666 (AU)

1.08 ± 0.10

1.89 ± 0.16 **

1.76 ± 0.31

2.11 ± 0.34

p-TBC1D1Thr590 (AU)

0.23 ± 0.05

0.29 ± 0.04

1.71 ± 0.19

1.18 ± 0.16 *

p-TBC1D1Ser700 (AU)

0.28 ± 0.04

0.42 ± 0.08

1.12 ± 0.19

0.81 ± 0.22

AS160 (AU)

0.50 ± 0.04

0.74 ± 0.08 *

1.63 ± 0.20

1.52 ± 0.25

TBC1D1 (AU)

0.25 ± 0.03

0.42 ± 0.06 *

1.47 ± 0.18

1.06 ± 0.18

  1. Data are expressed as mean ± SEM
  2. *P < 0.05 vs. WT mice; **P < 0.001 vs. WT mice; ***P < 0.0001 vs. WT mice
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Skeletal Muscle

ISSN: 2044-5040

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